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Assay Detail

CHEMBL1786818

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Dictyostelium discoideum myosin 2 motor domain-activated ATPase activity by spectrophotometry based PK/LDH coupled ATPase assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Dictyostelium discoideum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of Myosin ATPase activity by halogenated pseudilins: a structure-activity study.
Preller M, Chinthalapudi K, Martin R, Knolker HJ, Manstein DJ.
J Med Chem (2011) 54 : 3675 -3685
PubMed 21534527 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.33 4.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1235156 PENTABROMOPSEUDILIN 1 4.61
CHEMBL1738810 TRIBROMODICHLOROPSEUDILIN 1 4.33
CHEMBL1784320 1 4.04
CHEMBL1784318 1 -
CHEMBL1784319 1 -
CHEMBL1784321 1 -
CHEMBL1784322 1 -
CHEMBL1738815 PENTACHLOROPSEUDILIN 1 -
CHEMBL1784323 1 -
CHEMBL1784324 1 -
CHEMBL1782079 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1235156 PENTABROMOPSEUDILIN IC50 = 24400.0 nM 4.61
CHEMBL1738810 TRIBROMODICHLOROPSEUDILIN IC50 = 47200.0 nM 4.33
CHEMBL1784320 IC50 = 91900.0 nM 4.04
CHEMBL1784318 IC50 > 1000000.0 nM -
CHEMBL1784319 IC50 > 1000000.0 nM -
CHEMBL1784321 IC50 = 125400.0 nM -
CHEMBL1784322 IC50 = 182200.0 nM -
CHEMBL1738815 PENTACHLOROPSEUDILIN IC50 = 126300.0 nM -
CHEMBL1784323 IC50 = 274500.0 nM -
CHEMBL1784324 IC50 - -
CHEMBL1782079 IC50 - -