Assay Detail
Binding
CHEMBL1786941
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Inhibition of porcine brain GSK3 assessed as incorporation of [gamma-33P]-ATP into YRRAAVPPSPSLSRHSSPHQSpEDEEE after 30 mins by scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.16 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296586 | KENPAULLONE | — | 1 | 7.11 |
| CHEMBL1782168 | — | — | 1 | 6.09 |
| CHEMBL430574 | PAULLONE | — | 1 | 5.96 |
| CHEMBL1782170 | — | — | 1 | 5.47 |
| CHEMBL1782169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296586 | KENPAULLONE | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1782168 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL430574 | PAULLONE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1782170 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1782169 | — | IC50 | > | 10000.0 | nM | - |