Assay Detail
Binding
CHEMBL1787522
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Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.26 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.46 |
| CHEMBL573127 | — | — | 1 | 7.30 |
| CHEMBL573335 | — | — | 1 | 7.30 |
| CHEMBL574780 | — | — | 1 | 7.29 |
| CHEMBL582841 | — | — | 1 | 7.29 |
| CHEMBL584387 | — | — | 1 | 7.28 |
| CHEMBL574779 | — | — | 1 | 7.28 |
| CHEMBL583171 | — | — | 1 | 7.28 |
| CHEMBL574783 | — | — | 1 | 7.27 |
| CHEMBL583971 | — | — | 1 | 7.24 |
| CHEMBL575660 | — | — | 1 | 7.21 |
| CHEMBL573859 | — | — | 1 | 7.17 |
| CHEMBL582965 | — | — | 1 | 7.16 |
| CHEMBL574245 | — | — | 1 | 7.13 |
| CHEMBL573381 | — | — | 1 | 7.01 |
| CHEMBL574782 | — | — | 1 | 6.97 |
| CHEMBL574246 | — | — | 1 | 6.41 |
| CHEMBL574021 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL573127 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL573335 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL574780 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL582841 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL584387 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL574779 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL583171 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL574783 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL583971 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL575660 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL573859 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL582965 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL574245 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL573381 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL574782 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL574246 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL574021 | — | Ki | = | 395.0 | nM | 6.40 |