Assay Detail

CHEMBL1787587

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of [3H]-(+)-MK801 from NMDA receptor PCP binding site

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists.

Utech T, Köhler J, Wünsch B.
Eur J Med Chem (2011) 46 : 2157 -2169
PubMed 21444132 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	7.67	7.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL305904	ETOXADROL	2.0	1	7.70
CHEMBL1165411	DEXOXADROL	2.0	1	7.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL305904	ETOXADROL	Ki	=	20.0	nM	7.70
CHEMBL1165411	DEXOXADROL	Ki	=	23.0	nM	7.64