Assay Detail
Binding
CHEMBL1787618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE assessed as inhibition of acetylthiocholine chloride substrate hydrolysis incubated for 15 mins before substrate addition measured by spectrophotometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.67 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783195 | — | — | 1 | 8.34 |
| CHEMBL1783237 | — | — | 1 | 8.34 |
| CHEMBL1783242 | — | — | 1 | 8.33 |
| CHEMBL1783241 | — | — | 1 | 8.21 |
| CHEMBL1783194 | — | — | 1 | 8.13 |
| CHEMBL1783239 | — | — | 1 | 7.90 |
| CHEMBL1783238 | — | — | 1 | 7.82 |
| CHEMBL1783240 | — | — | 1 | 7.82 |
| CHEMBL1783192 | — | — | 1 | 7.59 |
| CHEMBL1783243 | — | — | 1 | 7.42 |
| CHEMBL1783193 | — | — | 1 | 7.36 |
| CHEMBL1783191 | — | — | 1 | 6.98 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 6.71 |
| CHEMBL1783190 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783195 | — | IC50 | = | 4.55 | nM | 8.34 |
| CHEMBL1783237 | — | IC50 | = | 4.61 | nM | 8.34 |
| CHEMBL1783242 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1783241 | — | IC50 | = | 6.14 | nM | 8.21 |
| CHEMBL1783194 | — | IC50 | = | 7.48 | nM | 8.13 |
| CHEMBL1783239 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL1783238 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL1783240 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL1783192 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL1783243 | — | IC50 | = | 38.5 | nM | 7.42 |
| CHEMBL1783193 | — | IC50 | = | 43.6 | nM | 7.36 |
| CHEMBL1783191 | — | IC50 | = | 104.4 | nM | 6.98 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL1783190 | — | IC50 | = | 365.2 | nM | 6.44 |