Assay Detail
Binding
CHEMBL1787753
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Inhibition of GST-tagged p38beta by fluorescence polarization method
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pKi | 4 | - | - |
| Ki | 3 | 7.33 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1784172 | — | — | 1 | 7.60 |
| CHEMBL1088752 | LOSMAPIMOD | 3.0 | 1 | 7.60 |
| CHEMBL1784173 | — | — | 1 | 6.80 |
| CHEMBL1784174 | — | — | 1 | - |
| CHEMBL1784175 | — | — | 1 | - |
| CHEMBL1784176 | — | — | 1 | - |
| CHEMBL1784177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1784172 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1088752 | LOSMAPIMOD | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1784173 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL1784174 | — | pKi | - | — | - | |
| CHEMBL1784175 | — | pKi | - | — | - | |
| CHEMBL1784176 | — | pKi | - | — | - | |
| CHEMBL1784177 | — | pKi | - | — | - |