Assay Detail
Binding
CHEMBL1787849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AL-11 from IRAP of CHO-K1 cell membrane after 30 mins by scintillation counting in presence of 30 mM EDTA and 600 uM 1,10-Phenantrone
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | CHO-K1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.41 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261120 | ANGIOTENSIN IV | — | 1 | 8.03 |
| CHEMBL1782887 | — | — | 1 | 8.01 |
| CHEMBL1782882 | — | — | 1 | 7.90 |
| CHEMBL1782888 | — | — | 1 | 7.61 |
| CHEMBL1782886 | — | — | 1 | 7.61 |
| CHEMBL1782883 | — | — | 1 | 7.54 |
| CHEMBL1782885 | — | — | 1 | 7.43 |
| CHEMBL1782881 | — | — | 1 | 7.33 |
| CHEMBL1782890 | — | — | 1 | 6.54 |
| CHEMBL1782889 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261120 | ANGIOTENSIN IV | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL1782887 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL1782882 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL1782888 | — | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL1782886 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL1782883 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL1782885 | — | Ki | = | 36.8 | nM | 7.43 |
| CHEMBL1782881 | — | Ki | = | 46.8 | nM | 7.33 |
| CHEMBL1782890 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL1782889 | — | Ki | = | 719.0 | nM | 6.14 |