Assay Detail
Binding
CHEMBL1787946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization assay
13
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.10 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472212 | — | — | 1 | 9.00 |
| CHEMBL2029181 | — | — | 3 | 6.10 |
| CHEMBL2029180 | — | — | 3 | 5.96 |
| CHEMBL519418 | — | — | 1 | 5.89 |
| CHEMBL1783837 | — | — | 1 | 5.68 |
| CHEMBL509485 | — | — | 1 | 5.42 |
| CHEMBL2029182 | — | — | 1 | - |
| CHEMBL2029183 | — | — | 1 | - |
| CHEMBL2448536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472212 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2029181 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2029181 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2029180 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL519418 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2029180 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1783837 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2029180 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2029181 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL509485 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2029182 | — | IC50 | - | — | - | |
| CHEMBL2029183 | — | IC50 | - | — | - | |
| CHEMBL2448536 | — | IC50 | - | — | - |