Assay Detail
Functional
CHEMBL1788083
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Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.36 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783728 | — | — | 1 | 8.80 |
| CHEMBL1783732 | — | — | 1 | 8.78 |
| CHEMBL1783731 | — | — | 1 | 8.65 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.37 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783728 | — | IC50 | = | 1.59 | nM | 8.80 |
| CHEMBL1783732 | — | IC50 | = | 1.65 | nM | 8.78 |
| CHEMBL1783731 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 4.24 | nM | 8.37 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 65.0 | nM | 7.19 |