Assay Detail
Functional
CHEMBL1788084
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Antiplasmodial activity against chloroquine-sensitive and mefloquine-resistant Plasmodium falciparum D6
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.11 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783728 | — | — | 1 | 8.33 |
| CHEMBL1783731 | — | — | 1 | 8.32 |
| CHEMBL1783732 | — | — | 1 | 8.30 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.84 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783728 | — | IC50 | = | 4.71 | nM | 8.33 |
| CHEMBL1783731 | — | IC50 | = | 4.75 | nM | 8.32 |
| CHEMBL1783732 | — | IC50 | = | 4.96 | nM | 8.30 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 16.9 | nM | 7.77 |