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Assay Detail

CHEMBL1794348

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504462, AID504475]
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Phospholipase A2 (CHEMBL4426)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.67 5.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1986418 1 5.61
CHEMBL3195142 1 5.26
CHEMBL1974450 1 4.98
CHEMBL1520424 1 4.97
CHEMBL1349405 1 4.96
CHEMBL1365132 1 4.87
CHEMBL1393538 1 4.75
CHEMBL3196472 1 4.65
CHEMBL1424479 1 4.46
CHEMBL602126 1 4.40
CHEMBL1351421 1 4.33
CHEMBL1584985 1 4.31
CHEMBL1340058 1 4.29
CHEMBL1541554 1 4.13
CHEMBL1540150 1 4.10
CHEMBL1388951 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1986418 IC50 = 2470.0 nM 5.61
CHEMBL3195142 IC50 = 5500.0 nM 5.26
CHEMBL1974450 IC50 = 10500.0 nM 4.98
CHEMBL1520424 IC50 = 10700.0 nM 4.97
CHEMBL1349405 IC50 = 11100.0 nM 4.96
CHEMBL1365132 IC50 = 13400.0 nM 4.87
CHEMBL1393538 IC50 = 17700.0 nM 4.75
CHEMBL3196472 IC50 = 22300.0 nM 4.65
CHEMBL1424479 IC50 = 35100.0 nM 4.46
CHEMBL602126 IC50 = 40100.0 nM 4.40
CHEMBL1351421 IC50 = 46400.0 nM 4.33
CHEMBL1584985 IC50 = 48900.0 nM 4.31
CHEMBL1340058 IC50 = 51700.0 nM 4.29
CHEMBL1541554 IC50 = 74100.0 nM 4.13
CHEMBL1540150 IC50 = 79100.0 nM 4.10
CHEMBL1388951 IC50 > 80000.0 nM -