Assay Detail
Binding
CHEMBL1798138
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Inhibition of Calmodulin-dependent PDE1 activity assessed as inorganic phosphate release after 30 min
22
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and docking studies of gigantol analogs as calmodulin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.49 | 5.03 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66917 | — | — | 1 | 5.03 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.99 |
| CHEMBL1796022 | DIPHENYLMETHANE | — | 1 | 4.82 |
| CHEMBL1796013 | — | — | 1 | 4.73 |
| CHEMBL268559 | — | — | 1 | 4.65 |
| CHEMBL1796026 | — | — | 1 | 4.64 |
| CHEMBL1796014 | — | — | 1 | 4.52 |
| CHEMBL1796012 | — | — | 1 | 4.50 |
| CHEMBL1796027 | — | — | 1 | 4.49 |
| CHEMBL1796015 | — | — | 1 | 4.44 |
| CHEMBL1796023 | — | — | 1 | 4.42 |
| CHEMBL1796017 | — | — | 1 | 4.34 |
| CHEMBL1796018 | — | — | 1 | 4.26 |
| CHEMBL1796021 | — | — | 1 | 4.26 |
| CHEMBL1796020 | — | — | 1 | 4.25 |
| CHEMBL1796024 | — | — | 1 | 4.24 |
| CHEMBL1796025 | — | — | 1 | 4.20 |
| CHEMBL1796016 | — | — | 1 | 4.12 |
| CHEMBL467338 | — | — | 1 | - |
| CHEMBL1796019 | BENZYLPHENYLETHER | — | 1 | - |
| CHEMBL219553 | GIGANTOL | — | 1 | - |
| CHEMBL440895 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66917 | — | IC50 | = | 9380.0 | nM | 5.03 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1796022 | DIPHENYLMETHANE | IC50 | = | 15020.0 | nM | 4.82 |
| CHEMBL1796013 | — | IC50 | = | 18440.0 | nM | 4.73 |
| CHEMBL268559 | — | IC50 | = | 22530.0 | nM | 4.65 |
| CHEMBL1796026 | — | IC50 | = | 22940.0 | nM | 4.64 |
| CHEMBL1796014 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL1796012 | — | IC50 | = | 31290.0 | nM | 4.50 |
| CHEMBL1796027 | — | IC50 | = | 32540.0 | nM | 4.49 |
| CHEMBL1796015 | — | IC50 | = | 36330.0 | nM | 4.44 |
| CHEMBL1796023 | — | IC50 | = | 37680.0 | nM | 4.42 |
| CHEMBL1796017 | — | IC50 | = | 46090.0 | nM | 4.34 |
| CHEMBL1796018 | — | IC50 | = | 54690.0 | nM | 4.26 |
| CHEMBL1796021 | — | IC50 | = | 54730.0 | nM | 4.26 |
| CHEMBL1796020 | — | IC50 | = | 56150.0 | nM | 4.25 |
| CHEMBL1796024 | — | IC50 | = | 57270.0 | nM | 4.24 |
| CHEMBL1796025 | — | IC50 | = | 62680.0 | nM | 4.20 |
| CHEMBL1796016 | — | IC50 | = | 75890.0 | nM | 4.12 |
| CHEMBL467338 | — | IC50 | = | 146350.0 | nM | - |
| CHEMBL1796019 | BENZYLPHENYLETHER | Inhibition | - | % | - | |
| CHEMBL219553 | GIGANTOL | IC50 | = | 114180.0 | nM | - |
| CHEMBL440895 | — | Inhibition | - | % | - |