Assay Detail
Binding
CHEMBL1798575
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Irreversible inhibition of LSD1
8
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of histone demethylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kinact | 5 | - | - |
| Ki | 3 | 5.08 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086217 | — | — | 2 | 5.08 |
| CHEMBL1797648 | — | — | 2 | 5.08 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | - |
| CHEMBL1797650 | — | — | 1 | - |
| CHEMBL1797651 | — | — | 1 | - |
| CHEMBL1797652 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086217 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL1797648 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL3989843 | TRANYLCYPROMINE | Ki | = | 357000.0 | nM | - |
| CHEMBL1086217 | — | Kinact | = | 0.25 | /min | - |
| CHEMBL1797648 | — | Kinact | = | 0.25 | /min | - |
| CHEMBL1797650 | — | Kinact | = | 0.1 | /min | - |
| CHEMBL1797651 | — | Kinact | = | 0.1 | /min | - |
| CHEMBL1797652 | — | Kinact | = | 0.25 | /min | - |