Assay Detail
Functional
CHEMBL1798628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced TNFalpha production
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.84 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088751 | PH-797804 | 2.0 | 1 | 8.23 |
| CHEMBL1738710 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088751 | PH-797804 | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1738710 | — | IC50 | = | 35.5 | nM | 7.45 |