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Assay Detail

CHEMBL1798962

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human MAO-B expressed in BTI insect cells using p-tyramine as substrate after 60 mins
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies.
Jagrat M, Behera J, Yabanoglu S, Ercan A, Ucar G, Sinha BN, Sankaran V, Basu A, Jayaprakash V.
Bioorg Med Chem Lett (2011) 21 : 4296 -4300
PubMed 21680183 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 5.37 7.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL972 SELEGILINE 4.0 1 7.04
CHEMBL1080035 1 6.09
CHEMBL86304 MOCLOBEMIDE 4.0 1 5.97
CHEMBL1796457 1 5.78
CHEMBL489743 1 5.75
CHEMBL1796456 1 5.73
CHEMBL1796454 1 5.50
CHEMBL1796458 1 5.40
CHEMBL1796459 1 5.39
CHEMBL1796461 1 5.38
CHEMBL1796460 1 5.32
CHEMBL1796455 1 5.32
CHEMBL1796448 1 4.66
CHEMBL1796443 1 4.22
CHEMBL1796447 1 4.22
CHEMBL1796444 1 4.16
CHEMBL1796449 1 -
CHEMBL1796453 1 -
CHEMBL1796446 1 -
CHEMBL1796452 1 -
CHEMBL1796451 1 -
CHEMBL1795357 1 -
CHEMBL1796445 1 -
CHEMBL1796450 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL972 SELEGILINE Ki = 91.0 nM 7.04
CHEMBL1080035 Ki = 805.0 nM 6.09
CHEMBL86304 MOCLOBEMIDE Ki = 1080.0 nM 5.97
CHEMBL1796457 Ki = 1660.0 nM 5.78
CHEMBL489743 Ki = 1800.0 nM 5.75
CHEMBL1796456 Ki = 1880.0 nM 5.73
CHEMBL1796454 Ki = 3200.0 nM 5.50
CHEMBL1796458 Ki = 4000.0 nM 5.40
CHEMBL1796459 Ki = 4110.0 nM 5.39
CHEMBL1796461 Ki = 4220.0 nM 5.38
CHEMBL1796460 Ki = 4800.0 nM 5.32
CHEMBL1796455 Ki = 4790.0 nM 5.32
CHEMBL1796448 Ki = 22000.0 nM 4.66
CHEMBL1796443 Ki = 60220.0 nM 4.22
CHEMBL1796447 Ki = 60000.0 nM 4.22
CHEMBL1796444 Ki = 69900.0 nM 4.16
CHEMBL1796449 Ki = 400900.0 nM -
CHEMBL1796453 Ki = 309220.0 nM -
CHEMBL1796446 Ki = 250000.0 nM -
CHEMBL1796452 Ki = 2130000.0 nM -
CHEMBL1796451 Ki = 255600.0 nM -
CHEMBL1795357 Ki = 355000.0 nM -
CHEMBL1796445 Ki = 979000.0 nM -
CHEMBL1796450 Ki = 300010.0 nM -