Assay Detail
Binding
CHEMBL1798975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of H+/K+ATPase in pig gastric microsome assessed as liberation of inorganic phosphate using ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Stomach |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A reverse method for diversity introduction of benzimidazole to synthesize H(+)/K(+)-ATP enzyme inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.12 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200930 | RABEPRAZOLE SODIUM | 4.0 | 1 | 5.82 |
| CHEMBL1796642 | — | — | 1 | 4.80 |
| CHEMBL1503 | OMEPRAZOLE | 4.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200930 | RABEPRAZOLE SODIUM | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1796642 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1503 | OMEPRAZOLE | IC50 | = | 18000.0 | nM | 4.75 |