Assay Detail
Binding
CHEMBL1799129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LSD1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.35 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795979 | — | — | 1 | 5.70 |
| CHEMBL1795980 | — | — | 1 | 5.70 |
| CHEMBL1795981 | — | — | 1 | 5.70 |
| CHEMBL1795978 | — | — | 1 | 5.22 |
| CHEMBL1795977 | — | — | 1 | 5.10 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795979 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1795980 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1795981 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1795978 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL1795977 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL3989843 | TRANYLCYPROMINE | Ki | = | 21000.0 | nM | 4.68 |