Assay Detail
Binding
CHEMBL1799219
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Inhibition of Klebsiella pneumoniae beta lactamase SHV-5
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Klebsiella pneumoniae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.66 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795564 | — | — | 2 | 4.82 |
| CHEMBL1795567 | — | — | 1 | 4.66 |
| CHEMBL1795568 | — | — | 1 | 4.57 |
| CHEMBL1795563 | — | — | 1 | - |
| CHEMBL1795565 | — | — | 1 | - |
| CHEMBL1795566 | — | — | 1 | - |
| CHEMBL1795569 | — | — | 1 | - |
| CHEMBL1795570 | — | — | 1 | - |
| CHEMBL1795571 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795564 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1795567 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1795564 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1795568 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1795563 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1795565 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1795566 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL1795569 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1795570 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1795571 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1795571 | — | IC50 | > | 50000.0 | nM | - |