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Assay Detail

CHEMBL1799237

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MCF7 cells after 72 hrs by cell counting kit analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.
Kawaratani Y, Harada T, Hirata Y, Nagaoka Y, Tanimura S, Shibano M, Taniguchi M, Yasuda M, Baba K, Uesato S.
Bioorg Med Chem (2011) 19 : 3995 -4003
PubMed 21664138 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.25 4.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1795736 1 4.26
CHEMBL1795731 1 4.24
CHEMBL1795732 1 -
CHEMBL1795733 1 -
CHEMBL1795734 1 -
CHEMBL1795735 1 -
CHEMBL1795737 1 -
CHEMBL1795738 1 -
CHEMBL115523 N-PHENYLBENZAMIDE 1 -
CHEMBL1795739 1 -
CHEMBL1795740 1 -
CHEMBL1795741 1 -
CHEMBL228226 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1795736 IC50 = 54300.0 nM 4.26
CHEMBL1795731 IC50 = 58100.0 nM 4.24
CHEMBL1795732 IC50 > 100000.0 nM -
CHEMBL1795733 IC50 > 100000.0 nM -
CHEMBL1795734 IC50 > 100000.0 nM -
CHEMBL1795735 IC50 > 100000.0 nM -
CHEMBL1795737 IC50 > 100000.0 nM -
CHEMBL1795738 IC50 > 100000.0 nM -
CHEMBL115523 N-PHENYLBENZAMIDE IC50 > 100000.0 nM -
CHEMBL1795739 IC50 > 100000.0 nM -
CHEMBL1795740 IC50 > 100000.0 nM -
CHEMBL1795741 IC50 > 100000.0 nM -
CHEMBL228226 IC50 > 100000.0 nM -