Assay Detail
Binding
CHEMBL1799285
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Inhibition of BACE1 by cell-free FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.35 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373533 | — | — | 1 | 8.30 |
| CHEMBL378225 | — | — | 1 | 7.82 |
| CHEMBL1795872 | — | — | 1 | 5.70 |
| CHEMBL1795874 | — | — | 1 | 5.62 |
| CHEMBL1795873 | — | — | 1 | 5.47 |
| CHEMBL1795871 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373533 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL378225 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1795872 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1795874 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1795873 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1795871 | — | IC50 | = | 7000.0 | nM | 5.16 |