Assay Detail
Binding
CHEMBL1799291
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Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate after 10 mins by Ellman's spectrophotometric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.61 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.60 |
| CHEMBL470768 | GINKGOLIC ACID 17:1 | — | 1 | 6.24 |
| CHEMBL470264 | — | — | 1 | 5.66 |
| CHEMBL1797234 | — | — | 1 | 5.50 |
| CHEMBL470127 | — | — | 1 | 4.88 |
| CHEMBL1797236 | — | — | 1 | 4.76 |
| CHEMBL1797235 | — | — | 1 | - |
| CHEMBL1797237 | — | — | 1 | - |
| CHEMBL1797238 | — | — | 1 | - |
| CHEMBL1797239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL470768 | GINKGOLIC ACID 17:1 | IC50 | = | 573.0 | nM | 6.24 |
| CHEMBL470264 | — | IC50 | = | 2172.0 | nM | 5.66 |
| CHEMBL1797234 | — | IC50 | = | 3182.0 | nM | 5.50 |
| CHEMBL470127 | — | IC50 | = | 13114.0 | nM | 4.88 |
| CHEMBL1797236 | — | IC50 | = | 17224.0 | nM | 4.76 |
| CHEMBL1797235 | — | IC50 | = | 342060.0 | nM | - |
| CHEMBL1797237 | — | IC50 | = | 178000.0 | nM | - |
| CHEMBL1797238 | — | IC50 | = | 358230.0 | nM | - |
| CHEMBL1797239 | — | IC50 | = | 303210.0 | nM | - |