Assay Detail
Binding
CHEMBL1799322
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Displacement of [125I]-IMPY from amyloid beta (1 to 42) after 2 hrs by gamma counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for β-amyloid plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.53 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1796238 | — | — | 1 | 8.18 |
| CHEMBL1796237 | — | — | 1 | 8.06 |
| CHEMBL78012 | — | — | 1 | 7.98 |
| CHEMBL1796236 | — | — | 1 | 7.46 |
| CHEMBL1796235 | — | — | 1 | 7.35 |
| CHEMBL1796234 | — | — | 1 | 6.88 |
| CHEMBL1796233 | — | — | 1 | 6.80 |
| CHEMBL1796231 | — | — | 1 | - |
| CHEMBL1796232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1796238 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL1796237 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL78012 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL1796236 | — | Ki | = | 34.5 | nM | 7.46 |
| CHEMBL1796235 | — | Ki | = | 44.9 | nM | 7.35 |
| CHEMBL1796234 | — | Ki | = | 133.2 | nM | 6.88 |
| CHEMBL1796233 | — | Ki | = | 156.6 | nM | 6.80 |
| CHEMBL1796231 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1796232 | — | Ki | > | 1000.0 | nM | - |