Assay Detail
Functional
CHEMBL1799374
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Cytotoxicity against human KB cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 10.17 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1797231 | CHAETOMUGILIN R | — | 1 | 10.17 |
| CHEMBL1797229 | CHAETOMUGILIN P | — | 1 | - |
| CHEMBL1797230 | CHAETOMUGILIN Q | — | 1 | - |
| CHEMBL1797232 | — | — | 1 | - |
| CHEMBL1797233 | CHAETOMUGILIN I | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1797231 | CHAETOMUGILIN R | IC50 | = | 0.0671 | nM | 10.17 |
| CHEMBL1797229 | CHAETOMUGILIN P | IC50 | = | 0.0018 | nM | - |
| CHEMBL1797230 | CHAETOMUGILIN Q | IC50 | > | 0.1 | nM | - |
| CHEMBL1797232 | — | IC50 | = | 0.0012 | nM | - |
| CHEMBL1797233 | CHAETOMUGILIN I | IC50 | = | 0.0023 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 0.0077 | nM | - |