Assay Detail
Functional
CHEMBL1799429
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-tumor activity of 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.83 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795676 | — | — | 1 | 7.66 |
| CHEMBL1795666 | — | — | 1 | 7.32 |
| CHEMBL196832 | — | — | 1 | 7.24 |
| CHEMBL1795660 | — | — | 1 | 6.92 |
| CHEMBL1795679 | — | — | 1 | 6.92 |
| CHEMBL1795659 | — | — | 1 | 6.68 |
| CHEMBL1795675 | — | — | 1 | 6.55 |
| CHEMBL1795835 | — | — | 1 | 6.49 |
| CHEMBL1795668 | — | — | 1 | 6.02 |
| CHEMBL1795667 | — | — | 1 | 5.98 |
| CHEMBL1795669 | — | — | 1 | 5.88 |
| CHEMBL1795661 | — | — | 1 | 5.80 |
| CHEMBL1795678 | — | — | 1 | 5.77 |
| CHEMBL1795665 | — | — | 1 | 5.74 |
| CHEMBL1795674 | — | — | 1 | 5.44 |
| CHEMBL1795664 | — | — | 1 | 5.42 |
| CHEMBL1795663 | — | — | 1 | 5.41 |
| CHEMBL1795677 | — | — | 1 | 5.24 |
| CHEMBL1795836 | — | — | 1 | 4.98 |
| CHEMBL1795662 | — | — | 1 | 4.91 |
| CHEMBL1795839 | — | — | 1 | 4.81 |
| CHEMBL1795837 | — | — | 1 | 4.76 |
| CHEMBL1795838 | — | — | 1 | 4.65 |
| CHEMBL1795670 | — | — | 1 | 4.58 |
| CHEMBL1795671 | — | — | 1 | 4.56 |
| CHEMBL1795673 | — | — | 1 | - |
| CHEMBL1795672 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795676 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1795666 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL196832 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1795660 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1795679 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1795659 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1795675 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1795835 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL1795668 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1795667 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1795669 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL1795661 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL1795678 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL1795665 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL1795674 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1795664 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL1795663 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL1795677 | — | IC50 | = | 5790.0 | nM | 5.24 |
| CHEMBL1795836 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1795662 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL1795839 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL1795837 | — | IC50 | = | 17540.0 | nM | 4.76 |
| CHEMBL1795838 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL1795670 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL1795671 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL1795673 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1795672 | — | IC50 | > | 100000.0 | nM | - |