Assay Detail
Binding
CHEMBL1799510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE by modified Ellman method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.47 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 6.92 |
| CHEMBL1795895 | — | — | 1 | 6.14 |
| CHEMBL1795891 | — | — | 1 | 5.92 |
| CHEMBL1795899 | — | — | 1 | 5.67 |
| CHEMBL1795892 | — | — | 1 | 5.29 |
| CHEMBL1795894 | — | — | 1 | 5.21 |
| CHEMBL1795890 | — | — | 1 | 5.16 |
| CHEMBL1795897 | — | — | 1 | 5.03 |
| CHEMBL1795896 | — | — | 1 | 4.95 |
| CHEMBL1795898 | — | — | 1 | 4.95 |
| CHEMBL1795893 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1795895 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1795891 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1795899 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL1795892 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL1795894 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1795890 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL1795897 | — | IC50 | = | 9260.0 | nM | 5.03 |
| CHEMBL1795896 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1795898 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1795893 | — | IC50 | = | 12160.0 | nM | 4.92 |