Assay Detail
Binding
CHEMBL1799737
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Inhibition of human recombinant renin using Q-FRET substrate after 3 hrs by fluorescence assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.71 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1796073 | — | — | 1 | 10.70 |
| CHEMBL1761519 | — | — | 1 | 10.70 |
| CHEMBL1796075 | — | — | 1 | 10.30 |
| CHEMBL1796074 | — | — | 1 | 10.22 |
| CHEMBL1796071 | — | — | 1 | 10.15 |
| CHEMBL1796070 | — | — | 1 | 9.92 |
| CHEMBL1796078 | — | — | 1 | 9.62 |
| CHEMBL1795909 | — | — | 1 | 9.52 |
| CHEMBL1796069 | — | — | 1 | 9.49 |
| CHEMBL1796065 | — | — | 1 | 9.40 |
| CHEMBL1795912 | — | — | 1 | 9.22 |
| CHEMBL1796061 | — | — | 1 | 9.22 |
| CHEMBL1796067 | — | — | 1 | 9.10 |
| CHEMBL1796077 | — | — | 1 | 9.06 |
| CHEMBL1796063 | — | — | 1 | 9.00 |
| CHEMBL1796066 | — | — | 1 | 8.85 |
| CHEMBL1796062 | — | — | 1 | 8.77 |
| CHEMBL1795907 | — | — | 1 | 8.70 |
| CHEMBL1796068 | — | — | 1 | 8.64 |
| CHEMBL1795911 | — | — | 1 | 8.52 |
| CHEMBL1795915 | — | — | 1 | 8.35 |
| CHEMBL1795913 | — | — | 1 | 8.31 |
| CHEMBL1796060 | — | — | 1 | 8.15 |
| CHEMBL1795910 | — | — | 1 | 8.10 |
| CHEMBL1795914 | — | — | 1 | 8.07 |
| CHEMBL1796072 | — | — | 1 | 7.92 |
| CHEMBL1795903 | — | — | 1 | 7.92 |
| CHEMBL1795906 | — | — | 1 | 7.89 |
| CHEMBL1796064 | — | — | 1 | 7.75 |
| CHEMBL1795908 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1796073 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1761519 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1796075 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1796074 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1796071 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1796070 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL1796078 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL1795909 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1796069 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL1796065 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1795912 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1796061 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1796067 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1796077 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL1796063 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1796066 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1796062 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1795907 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1796068 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1795911 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1795915 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1795913 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1796060 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1795910 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1795914 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1795903 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1796072 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1795906 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1796064 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1795908 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1795905 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1795902 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1795916 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1795901 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1795904 | — | IC50 | = | 200.0 | nM | 6.70 |