Assay Detail
Binding
CHEMBL1799739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 5.11 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1796075 | — | — | 1 | 6.12 |
| CHEMBL1761519 | — | — | 1 | 6.10 |
| CHEMBL1796073 | — | — | 1 | 6.02 |
| CHEMBL1796074 | — | — | 1 | 5.92 |
| CHEMBL1796064 | — | — | 1 | 5.77 |
| CHEMBL1795909 | — | — | 1 | 5.32 |
| CHEMBL1796062 | — | — | 1 | 5.30 |
| CHEMBL1795907 | — | — | 1 | 5.17 |
| CHEMBL1795901 | — | — | 1 | 5.14 |
| CHEMBL1795911 | — | — | 1 | 5.12 |
| CHEMBL1795913 | — | — | 1 | 5.08 |
| CHEMBL1796071 | — | — | 1 | 4.96 |
| CHEMBL1795912 | — | — | 1 | 4.96 |
| CHEMBL1796077 | — | — | 1 | 4.92 |
| CHEMBL1795908 | — | — | 1 | 4.89 |
| CHEMBL1796078 | — | — | 1 | 4.82 |
| CHEMBL1795916 | — | — | 1 | 4.82 |
| CHEMBL1795914 | — | — | 1 | 4.77 |
| CHEMBL1796065 | — | — | 1 | 4.77 |
| CHEMBL1796060 | — | — | 1 | 4.75 |
| CHEMBL1796063 | — | — | 1 | 4.75 |
| CHEMBL1796070 | — | — | 1 | 4.64 |
| CHEMBL1796067 | — | — | 1 | 4.57 |
| CHEMBL1795906 | — | — | 1 | 4.55 |
| CHEMBL1795910 | — | — | 1 | 4.55 |
| CHEMBL1795902 | — | — | 1 | - |
| CHEMBL1795903 | — | — | 1 | - |
| CHEMBL1795904 | — | — | 1 | - |
| CHEMBL1795905 | — | — | 1 | - |
| CHEMBL1796072 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1796075 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL1761519 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1796073 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL1796074 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1796064 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL1795909 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL1796062 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL1795907 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL1795901 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL1795911 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL1795913 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL1796071 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1795912 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1796077 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1795908 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL1796078 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL1795916 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL1795914 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL1796065 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL1796060 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1796063 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1796070 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL1796067 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL1795906 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL1795910 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL1796061 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1795915 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1796066 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1796068 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1796069 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1796072 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1795905 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1795904 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1795903 | — | Ki | > | 29000.0 | nM | - |
| CHEMBL1795902 | — | Ki | > | 29000.0 | nM | - |