Assay Detail

CHEMBL1803131

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of alpha-adrenergic receptor

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthesis, evaluation and metabolic studies of radiotracers containing a 4-(4-[18F]-fluorobenzyl)piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors.

Labas R, Gilbert G, Nicole O, Dhilly M, Abbas A, Tirel O, Buisson A, Henry J, Barré L, Debruyne D, Sobrio F.
Eur J Med Chem (2011) 46 : 2295 -2309
PubMed 21453995 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.21	6.21

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL64941	—	—	1	6.21

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL64941	—	IC50	=	620.0	nM	6.21