Assay Detail
Functional
CHEMBL1803221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells after 48 hrs by sulforhodamine B assay
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 75 | 7.13 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802510 | — | — | 1 | 8.40 |
| CHEMBL1802509 | — | — | 1 | 8.10 |
| CHEMBL1802511 | — | — | 1 | 8.00 |
| CHEMBL1802998 | — | — | 1 | 8.00 |
| CHEMBL1802503 | — | — | 1 | 7.96 |
| CHEMBL1802501 | — | — | 1 | 7.82 |
| CHEMBL1802500 | — | — | 1 | 7.75 |
| CHEMBL1802499 | — | — | 1 | 7.54 |
| CHEMBL1803003 | — | — | 1 | 7.54 |
| CHEMBL1803000 | — | — | 1 | 7.52 |
| CHEMBL1802996 | — | — | 1 | 7.51 |
| CHEMBL1802506 | — | — | 1 | 7.50 |
| CHEMBL1802574 | — | — | 1 | 7.48 |
| CHEMBL1802498 | — | — | 1 | 7.47 |
| CHEMBL1802507 | — | — | 1 | 7.47 |
| CHEMBL1802513 | — | — | 1 | 7.44 |
| CHEMBL1802584 | — | — | 1 | 7.40 |
| CHEMBL1803002 | — | — | 1 | 7.39 |
| CHEMBL1802502 | — | — | 1 | 7.38 |
| CHEMBL1802999 | — | — | 1 | 7.38 |
| CHEMBL1802560 | — | — | 1 | 7.36 |
| CHEMBL1802993 | — | — | 1 | 7.29 |
| CHEMBL1802997 | — | — | 1 | 7.29 |
| CHEMBL1802994 | — | — | 1 | 7.26 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.21 |
| CHEMBL1802581 | — | — | 1 | 7.21 |
| CHEMBL1802992 | — | — | 1 | 7.18 |
| CHEMBL1802508 | — | — | 1 | 7.17 |
| CHEMBL1802570 | — | — | 1 | 7.16 |
| CHEMBL1802514 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802510 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1802509 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1802998 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1802511 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1802503 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1802501 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1802500 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1802499 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1803003 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1803000 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1802996 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1802506 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1802574 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1802498 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1802507 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1802513 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1802584 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1803002 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1802502 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1802999 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1802560 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1802993 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1802997 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1802994 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1802581 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1802992 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1802508 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1802570 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1802514 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1802575 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1802512 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1802582 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1802558 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1802564 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1802504 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1802561 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1803001 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1802565 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1802576 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1802577 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1800100 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL441724 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1802566 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1802557 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1802569 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1802583 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1802995 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1803058 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1802578 | — | IC50 | = | 430.0 | nM | 6.37 |