Assay Detail
Functional
CHEMBL1803222
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B assay
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 75 | 7.27 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802510 | — | — | 1 | 8.40 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.37 |
| CHEMBL1802509 | — | — | 1 | 8.37 |
| CHEMBL1802511 | — | — | 1 | 8.09 |
| CHEMBL1802998 | — | — | 1 | 8.07 |
| CHEMBL1802501 | — | — | 1 | 8.04 |
| CHEMBL1802503 | — | — | 1 | 8.00 |
| CHEMBL1802500 | — | — | 1 | 7.92 |
| CHEMBL1803003 | — | — | 1 | 7.82 |
| CHEMBL1802513 | — | — | 1 | 7.82 |
| CHEMBL1802507 | — | — | 1 | 7.82 |
| CHEMBL1802506 | — | — | 1 | 7.80 |
| CHEMBL1802996 | — | — | 1 | 7.77 |
| CHEMBL1802499 | — | — | 1 | 7.62 |
| CHEMBL1802584 | — | — | 1 | 7.62 |
| CHEMBL1802574 | — | — | 1 | 7.58 |
| CHEMBL1802498 | — | — | 1 | 7.57 |
| CHEMBL1803000 | — | — | 1 | 7.51 |
| CHEMBL1802502 | — | — | 1 | 7.51 |
| CHEMBL1802993 | — | — | 1 | 7.47 |
| CHEMBL1803002 | — | — | 1 | 7.46 |
| CHEMBL1802560 | — | — | 1 | 7.41 |
| CHEMBL1802997 | — | — | 1 | 7.41 |
| CHEMBL1802994 | — | — | 1 | 7.40 |
| CHEMBL1802999 | — | — | 1 | 7.39 |
| CHEMBL1802514 | — | — | 1 | 7.37 |
| CHEMBL1802508 | — | — | 1 | 7.35 |
| CHEMBL1802992 | — | — | 1 | 7.35 |
| CHEMBL1802512 | — | — | 1 | 7.33 |
| CHEMBL1802504 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802510 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1802509 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1802511 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL1802998 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1802501 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL1802503 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1802500 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1803003 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1802513 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1802507 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1802506 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1802996 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1802584 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1802499 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1802574 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1802498 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1803000 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1802502 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1802993 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1803002 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1802560 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1802997 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1802994 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1802999 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1802514 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1802992 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1802508 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1802512 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1802504 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1802581 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1802575 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1802564 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1802558 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1802582 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1802570 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1802565 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1802576 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1802561 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1802577 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1800100 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1802566 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1802557 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1803001 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1802583 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1802569 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1802995 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1802505 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1803058 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL441724 | — | IC50 | = | 230.0 | nM | 6.64 |