Assay Detail
Functional
CHEMBL1803315
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells after 48 hrs by sulforhodamine B assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.95 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.44 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.15 |
| CHEMBL1802510 | — | — | 1 | 8.60 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.17 |
| CHEMBL1802511 | — | — | 1 | 8.14 |
| CHEMBL1802509 | — | — | 1 | 8.12 |
| CHEMBL1802503 | — | — | 1 | 7.85 |
| CHEMBL1802501 | — | — | 1 | 7.80 |
| CHEMBL1802998 | — | — | 1 | 7.75 |
| CHEMBL1802500 | — | — | 1 | 7.75 |
| CHEMBL1803003 | — | — | 1 | 7.19 |
| CHEMBL1802565 | — | — | 1 | 6.75 |
| CHEMBL1802577 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL1802510 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL107 | COLCHICINE | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1802511 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1802509 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL1802503 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1802501 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1802998 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1802500 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1803003 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1802565 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1802577 | — | IC50 | = | 240.0 | nM | 6.62 |