Assay Detail
Functional
CHEMBL1803361
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Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as decrease in intracellular viral DNA measured 24 hrs after last dose
45
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.74 | 6.34 |
| EC90 | 22 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1545 | TIZOXANIDE | -1.0 | 2 | 6.34 |
| CHEMBL1801519 | — | — | 2 | 6.27 |
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 2 | 6.23 |
| CHEMBL1801507 | — | — | 2 | 6.23 |
| CHEMBL1802240 | — | — | 2 | 6.18 |
| CHEMBL1802242 | — | — | 2 | 6.14 |
| CHEMBL1241274 | — | — | 2 | 6.05 |
| CHEMBL1241273 | — | — | 2 | 6.00 |
| CHEMBL1802239 | — | — | 2 | 5.68 |
| CHEMBL1241146 | — | — | 2 | 5.68 |
| CHEMBL1241302 | — | — | 2 | 5.57 |
| CHEMBL1241394 | — | — | 2 | 5.54 |
| CHEMBL1801509 | — | — | 2 | 5.46 |
| CHEMBL1241243 | — | — | 2 | 5.38 |
| CHEMBL1801516 | — | — | 2 | 5.26 |
| CHEMBL1241359 | — | — | 2 | 5.12 |
| CHEMBL1801511 | — | — | 2 | 5.11 |
| CHEMBL1801518 | — | — | 2 | 5.04 |
| CHEMBL1241275 | — | — | 2 | - |
| CHEMBL1240618 | — | — | 1 | - |
| CHEMBL1801514 | — | — | 2 | - |
| CHEMBL1801510 | — | — | 2 | - |
| CHEMBL1802238 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1545 | TIZOXANIDE | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1801519 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1801507 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1401 | NITAZOXANIDE | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1802240 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1802242 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1241274 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1241273 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1241146 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1802239 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1241302 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1241394 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1801509 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1241243 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1801516 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1241359 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1801511 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1801518 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL1802238 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1801510 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1801514 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1240618 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1241275 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1802238 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1801510 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1801514 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1401 | NITAZOXANIDE | EC90 | = | 2.1 | uM | - |
| CHEMBL1545 | TIZOXANIDE | EC90 | = | 1.2 | uM | - |
| CHEMBL1241273 | — | EC90 | = | 2.9 | uM | - |
| CHEMBL1241146 | — | EC90 | = | 12.0 | uM | - |
| CHEMBL1241243 | — | EC90 | = | 15.0 | uM | - |
| CHEMBL1241275 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1802242 | — | EC90 | = | 3.3 | uM | - |
| CHEMBL1802239 | — | EC90 | = | 6.8 | uM | - |
| CHEMBL1801519 | — | EC90 | = | 1.8 | uM | - |
| CHEMBL1801518 | — | EC90 | = | 27.0 | uM | - |
| CHEMBL1801516 | — | EC90 | = | 14.0 | uM | - |
| CHEMBL1801511 | — | EC90 | = | 30.0 | uM | - |
| CHEMBL1241302 | — | EC90 | = | 6.3 | uM | - |
| CHEMBL1802240 | — | EC90 | = | 1.7 | uM | - |
| CHEMBL1241359 | — | EC90 | = | 22.0 | uM | - |
| CHEMBL1801507 | — | EC90 | = | 3.9 | uM | - |
| CHEMBL1241394 | — | EC90 | = | 8.7 | uM | - |
| CHEMBL1801509 | — | EC90 | = | 11.0 | uM | - |
| CHEMBL1241274 | — | EC90 | = | 2.0 | uM | - |