Assay Detail
Functional
CHEMBL1803448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by sulforhodamine B assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-TAX 5-6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.64 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802510 | — | — | 1 | 8.52 |
| CHEMBL1802509 | — | — | 1 | 8.28 |
| CHEMBL1802511 | — | — | 1 | 8.21 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.16 |
| CHEMBL1802503 | — | — | 1 | 8.05 |
| CHEMBL1802501 | — | — | 1 | 8.03 |
| CHEMBL1802500 | — | — | 1 | 7.92 |
| CHEMBL1802998 | — | — | 1 | 7.85 |
| CHEMBL1803003 | — | — | 1 | 7.42 |
| CHEMBL1802565 | — | — | 1 | 7.07 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.85 |
| CHEMBL1802577 | — | — | 1 | 6.70 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802510 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1802509 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1802511 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1802503 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL1802501 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL1802500 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1802998 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1803003 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1802565 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL107 | COLCHICINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1802577 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 520.0 | nM | 6.28 |