Assay Detail
Binding
CHEMBL1803471
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Inhibition of human ERG expressed in CHO cells by Q-patch assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazolopiperazines: hit to lead optimization of new antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.21 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800770 | — | — | 1 | 5.82 |
| CHEMBL1800772 | — | — | 1 | 5.64 |
| CHEMBL1800774 | — | — | 1 | 5.32 |
| CHEMBL1800137 | — | — | 1 | 5.25 |
| CHEMBL1800776 | — | — | 1 | 5.25 |
| CHEMBL1800768 | — | — | 1 | 5.24 |
| CHEMBL1800769 | — | — | 1 | 4.96 |
| CHEMBL601821 | — | — | 1 | 4.72 |
| CHEMBL1800775 | — | — | 1 | 4.68 |
| CHEMBL1800836 | — | — | 1 | - |
| CHEMBL1800831 | — | — | 1 | - |
| CHEMBL1800771 | — | — | 1 | - |
| CHEMBL1800773 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800770 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1800772 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1800774 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1800137 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1800776 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1800768 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1800769 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL601821 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1800775 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1800836 | — | IC50 | - | — | - | |
| CHEMBL1800831 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1800771 | — | IC50 | - | — | - | |
| CHEMBL1800773 | — | IC50 | - | — | - |