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Assay Detail

CHEMBL1803587

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of DXR
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.
Deng L, Diao J, Chen P, Pujari V, Yao Y, Cheng G, Crick DC, Prasad BV, Song Y.
J Med Chem (2011) 54 : 4721 -4734
PubMed 21561155 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.28 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291727 1 5.40
CHEMBL54714 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291727 IC50 = 4000.0 nM 5.40
CHEMBL54714 IC50 = 7000.0 nM 5.16