Assay Detail
Binding
CHEMBL1803828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (CHEMBL1293255) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.65 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800139 | — | — | 1 | 8.10 |
| CHEMBL1800143 | — | — | 1 | 8.00 |
| CHEMBL1800140 | — | — | 1 | 7.72 |
| CHEMBL1800144 | — | — | 1 | 7.62 |
| CHEMBL1800138 | — | — | 1 | 7.60 |
| CHEMBL1800142 | — | — | 1 | 7.55 |
| CHEMBL1800141 | — | — | 1 | 7.33 |
| CHEMBL599406 | — | — | 1 | 7.29 |
| CHEMBL1800076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800139 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1800143 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1800140 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1800144 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1800138 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1800142 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1800141 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL599406 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1800076 | — | IC50 | > | 50000.0 | nM | - |