Assay Detail
Binding
CHEMBL1804183
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Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.75 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802450 | — | — | 1 | 7.01 |
| CHEMBL1801542 | — | — | 1 | 6.88 |
| CHEMBL7301 | FENRETINIDE | 3.0 | 1 | 6.81 |
| CHEMBL1803043 | — | — | 1 | 6.75 |
| CHEMBL986 | RETINOL | 4.0 | 1 | 6.74 |
| CHEMBL60405 | — | — | 1 | 6.67 |
| CHEMBL1802454 | — | — | 1 | 6.64 |
| CHEMBL58106 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802450 | — | Kd | = | 98.0 | nM | 7.01 |
| CHEMBL1801542 | — | Kd | = | 131.0 | nM | 6.88 |
| CHEMBL7301 | FENRETINIDE | Kd | = | 156.0 | nM | 6.81 |
| CHEMBL1803043 | — | Kd | = | 178.0 | nM | 6.75 |
| CHEMBL986 | RETINOL | Kd | = | 182.0 | nM | 6.74 |
| CHEMBL60405 | — | Kd | = | 214.0 | nM | 6.67 |
| CHEMBL1802454 | — | Kd | = | 227.0 | nM | 6.64 |
| CHEMBL58106 | — | Kd | = | 333.0 | nM | 6.48 |