Assay Detail
Binding
CHEMBL1804237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CDK5/p25 using Histone H1 and [gamma32]-ATP after 30 mins by scintillation counting
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.52 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802410 | — | — | 1 | 6.18 |
| CHEMBL1802966 | — | — | 1 | 6.17 |
| CHEMBL44541 | MERIDIANIN C | — | 1 | 5.92 |
| CHEMBL46440 | MERIDIANIN D | — | 1 | 5.92 |
| CHEMBL1802406 | — | — | 1 | 5.85 |
| CHEMBL1802404 | — | — | 1 | 5.80 |
| CHEMBL1802403 | — | — | 1 | 5.80 |
| CHEMBL1802965 | — | — | 1 | 5.75 |
| CHEMBL1802967 | — | — | 1 | 5.68 |
| CHEMBL1802963 | — | — | 1 | 5.51 |
| CHEMBL1802392 | — | — | 1 | 5.33 |
| CHEMBL48082 | — | — | 1 | 5.30 |
| CHEMBL1802396 | — | — | 1 | 5.22 |
| CHEMBL1802409 | — | — | 1 | 5.21 |
| CHEMBL1802401 | — | — | 1 | 5.20 |
| CHEMBL1802389 | — | — | 1 | 5.17 |
| CHEMBL1802968 | — | — | 1 | 5.16 |
| CHEMBL1802397 | — | — | 1 | 5.12 |
| CHEMBL1802391 | — | — | 1 | 5.12 |
| CHEMBL1802962 | — | — | 1 | 5.00 |
| CHEMBL1802393 | — | — | 1 | - |
| CHEMBL1802390 | — | — | 1 | - |
| CHEMBL1802394 | — | — | 1 | - |
| CHEMBL1802972 | — | — | 1 | - |
| CHEMBL1802971 | — | — | 1 | - |
| CHEMBL1802970 | — | — | 1 | - |
| CHEMBL1802969 | — | — | 1 | - |
| CHEMBL1802395 | — | — | 1 | - |
| CHEMBL1802398 | — | — | 1 | - |
| CHEMBL1802399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802410 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1802966 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL44541 | MERIDIANIN C | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL46440 | MERIDIANIN D | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1802406 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1802404 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1802403 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1802965 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1802967 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1802963 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1802392 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL48082 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1802396 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1802409 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1802401 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1802389 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1802968 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1802391 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1802397 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1802962 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1802408 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802407 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802405 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802402 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802400 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802399 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802398 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802395 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802970 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802971 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802972 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802394 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802390 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802393 | — | IC50 | > | 10000.0 | nM | - |