Assay Detail
Functional
CHEMBL1804401
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Antiproliferative activity against human PC3 cells after 48 hrs by resazurin reduction test
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.93 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802966 | — | — | 1 | 5.54 |
| CHEMBL1802971 | — | — | 1 | 5.44 |
| CHEMBL1802391 | — | — | 1 | 5.30 |
| CHEMBL1802405 | — | — | 1 | 5.22 |
| CHEMBL1802402 | — | — | 1 | 5.16 |
| CHEMBL1802395 | — | — | 1 | 5.10 |
| CHEMBL1802406 | — | — | 1 | 4.97 |
| CHEMBL1802404 | — | — | 1 | 4.96 |
| CHEMBL1802410 | — | — | 1 | 4.85 |
| CHEMBL1802390 | — | — | 1 | 4.85 |
| CHEMBL1802967 | — | — | 1 | 4.82 |
| CHEMBL1802403 | — | — | 1 | 4.58 |
| CHEMBL1802399 | — | — | 1 | 4.54 |
| CHEMBL1802409 | — | — | 1 | 4.33 |
| CHEMBL1802408 | — | — | 1 | 4.32 |
| CHEMBL1802963 | — | — | 1 | - |
| CHEMBL46440 | MERIDIANIN D | — | 1 | - |
| CHEMBL44541 | MERIDIANIN C | — | 1 | - |
| CHEMBL1802962 | — | — | 1 | - |
| CHEMBL1802392 | — | — | 1 | - |
| CHEMBL1802393 | — | — | 1 | - |
| CHEMBL1802389 | — | — | 1 | - |
| CHEMBL1802396 | — | — | 1 | - |
| CHEMBL1802397 | — | — | 1 | - |
| CHEMBL1802398 | — | — | 1 | - |
| CHEMBL1802394 | — | — | 1 | - |
| CHEMBL1802400 | — | — | 1 | - |
| CHEMBL1802401 | — | — | 1 | - |
| CHEMBL48082 | — | — | 1 | - |
| CHEMBL1802407 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802966 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1802971 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1802391 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1802405 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1802402 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1802395 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1802406 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL1802404 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1802410 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1802390 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1802967 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1802403 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1802399 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1802409 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1802408 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1802972 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802970 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL1802969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802968 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802965 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802963 | — | IC50 | - | — | - | |
| CHEMBL46440 | MERIDIANIN D | IC50 | - | — | - | |
| CHEMBL44541 | MERIDIANIN C | IC50 | - | — | - | |
| CHEMBL1802962 | — | IC50 | - | — | - | |
| CHEMBL1802392 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802393 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802389 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802397 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802398 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802394 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802400 | — | IC50 | - | — | - | |
| CHEMBL1802401 | — | IC50 | - | — | - | |
| CHEMBL48082 | — | IC50 | - | — | - | |
| CHEMBL1802407 | — | IC50 | > | 50000.0 | nM | - |