Assay Detail
Functional
CHEMBL1804405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Pyroglutamylated RF-amide peptide receptor (CHEMBL5852) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of a series of analogues of the RFamide-related peptide 26RFa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 6.38 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802414 | — | — | 1 | 8.31 |
| CHEMBL1802413 | — | — | 1 | 7.98 |
| CHEMBL1802418 | — | — | 1 | 7.52 |
| CHEMBL1802419 | — | — | 1 | 7.43 |
| CHEMBL1802480 | — | — | 1 | 7.41 |
| CHEMBL1800099 | — | — | 1 | 7.37 |
| CHEMBL1802482 | — | — | 1 | 7.17 |
| CHEMBL1802420 | — | — | 1 | 7.02 |
| CHEMBL1802416 | — | — | 1 | 6.86 |
| CHEMBL1802373 | — | — | 1 | 6.78 |
| CHEMBL1802417 | — | — | 1 | 6.73 |
| CHEMBL1802369 | — | — | 1 | 6.63 |
| CHEMBL1802423 | — | — | 1 | 6.63 |
| CHEMBL1802421 | — | — | 1 | 6.62 |
| CHEMBL1802476 | — | — | 1 | 6.55 |
| CHEMBL1802422 | — | — | 1 | 6.55 |
| CHEMBL1802370 | — | — | 1 | 6.45 |
| CHEMBL1802372 | — | — | 1 | 6.43 |
| CHEMBL1802379 | — | — | 1 | 6.34 |
| CHEMBL1802377 | — | — | 1 | 6.23 |
| CHEMBL1802378 | — | — | 1 | 6.16 |
| CHEMBL1802375 | — | — | 1 | 6.14 |
| CHEMBL1802425 | — | — | 1 | 6.13 |
| CHEMBL1802365 | — | — | 1 | 6.13 |
| CHEMBL1802366 | — | — | 1 | 6.09 |
| CHEMBL1802380 | — | — | 1 | 6.08 |
| CHEMBL1802376 | — | — | 1 | 6.08 |
| CHEMBL1802371 | — | — | 1 | 5.96 |
| CHEMBL1802479 | — | — | 1 | 5.96 |
| CHEMBL1802478 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802414 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1802413 | — | EC50 | = | 10.4 | nM | 7.98 |
| CHEMBL1802418 | — | EC50 | = | 30.2 | nM | 7.52 |
| CHEMBL1802419 | — | EC50 | = | 37.5 | nM | 7.43 |
| CHEMBL1802480 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1800099 | — | EC50 | = | 43.2 | nM | 7.37 |
| CHEMBL1802482 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1802420 | — | EC50 | = | 95.3 | nM | 7.02 |
| CHEMBL1802416 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL1802373 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL1802417 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL1802423 | — | EC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1802369 | — | EC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1802421 | — | EC50 | = | 237.0 | nM | 6.62 |
| CHEMBL1802422 | — | EC50 | = | 282.0 | nM | 6.55 |
| CHEMBL1802476 | — | EC50 | = | 282.0 | nM | 6.55 |
| CHEMBL1802370 | — | EC50 | = | 355.0 | nM | 6.45 |
| CHEMBL1802372 | — | EC50 | = | 374.0 | nM | 6.43 |
| CHEMBL1802379 | — | EC50 | = | 455.0 | nM | 6.34 |
| CHEMBL1802377 | — | EC50 | = | 588.0 | nM | 6.23 |
| CHEMBL1802378 | — | EC50 | = | 695.0 | nM | 6.16 |
| CHEMBL1802375 | — | EC50 | = | 722.0 | nM | 6.14 |
| CHEMBL1802365 | — | EC50 | = | 741.0 | nM | 6.13 |
| CHEMBL1802425 | — | EC50 | = | 739.0 | nM | 6.13 |
| CHEMBL1802366 | — | EC50 | = | 817.0 | nM | 6.09 |
| CHEMBL1802380 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1802376 | — | EC50 | = | 826.0 | nM | 6.08 |
| CHEMBL1802371 | — | EC50 | = | 1103.0 | nM | 5.96 |
| CHEMBL1802479 | — | EC50 | = | 1088.0 | nM | 5.96 |
| CHEMBL1802478 | — | EC50 | = | 1198.0 | nM | 5.92 |
| CHEMBL1802412 | — | EC50 | = | 1308.0 | nM | 5.88 |
| CHEMBL1802433 | — | EC50 | = | 1333.0 | nM | 5.88 |
| CHEMBL1802484 | — | EC50 | = | 1443.0 | nM | 5.84 |
| CHEMBL1802364 | — | EC50 | = | 1471.0 | nM | 5.83 |
| CHEMBL1802368 | — | EC50 | = | 1631.0 | nM | 5.79 |
| CHEMBL1802424 | — | EC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL1802367 | — | EC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL1802374 | — | EC50 | = | 2545.0 | nM | 5.59 |
| CHEMBL1802415 | — | EC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL1802432 | — | EC50 | = | 2985.0 | nM | 5.53 |
| CHEMBL1802431 | — | EC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL1802438 | — | EC50 | = | 4975.0 | nM | 5.30 |