Assay Detail
Functional
CHEMBL1804653
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Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.11 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.77 |
| CHEMBL1800905 | — | — | 1 | 8.51 |
| CHEMBL1800904 | — | — | 1 | 7.77 |
| CHEMBL1800907 | — | — | 1 | 7.70 |
| CHEMBL1800906 | — | — | 1 | 6.77 |
| CHEMBL1800903 | — | — | 1 | 6.70 |
| CHEMBL1800908 | — | — | 1 | 6.52 |
| CHEMBL1800602 | — | — | 1 | 6.38 |
| CHEMBL1800604 | — | — | 1 | 6.38 |
| CHEMBL1800902 | — | — | 1 | 6.38 |
| CHEMBL1800620 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1800905 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1800904 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1800907 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1800906 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1800903 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1800908 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1800602 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1800604 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1800902 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1800620 | — | IC50 | = | 430.0 | nM | 6.37 |