Assay Detail
Binding
CHEMBL1805101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK1 (CHEMBL1075280) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.67 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802358 | — | — | 1 | 7.82 |
| CHEMBL1803085 | — | — | 1 | 7.22 |
| CHEMBL1802852 | — | — | 1 | 7.14 |
| CHEMBL1802855 | — | — | 1 | 7.10 |
| CHEMBL1803069 | — | — | 1 | 7.08 |
| CHEMBL1803083 | — | — | 1 | 7.08 |
| CHEMBL1802846 | — | — | 1 | 6.92 |
| CHEMBL1802851 | — | — | 1 | 6.92 |
| CHEMBL1803079 | — | — | 1 | 6.89 |
| CHEMBL1802845 | — | — | 1 | 6.89 |
| CHEMBL1802849 | — | — | 1 | 6.89 |
| CHEMBL1802854 | — | — | 1 | 6.85 |
| CHEMBL1802850 | — | — | 1 | 6.85 |
| CHEMBL1803072 | — | — | 1 | 6.80 |
| CHEMBL1802847 | — | — | 1 | 6.80 |
| CHEMBL1802842 | — | — | 1 | 6.77 |
| CHEMBL1802356 | — | — | 1 | 6.77 |
| CHEMBL1179821 | — | — | 1 | 6.72 |
| CHEMBL1803067 | — | — | 1 | 6.70 |
| CHEMBL1802848 | — | — | 1 | 6.70 |
| CHEMBL1803073 | — | — | 1 | 6.66 |
| CHEMBL1803068 | — | — | 1 | 6.64 |
| CHEMBL1802853 | — | — | 1 | 6.63 |
| CHEMBL1802844 | — | — | 1 | 6.58 |
| CHEMBL1802843 | — | — | 1 | 6.51 |
| CHEMBL1802357 | — | — | 1 | 6.50 |
| CHEMBL1803084 | — | — | 1 | 6.50 |
| CHEMBL485053 | LEUCETTAMINE B | — | 1 | 6.40 |
| CHEMBL1803082 | — | — | 1 | 6.40 |
| CHEMBL1803071 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802358 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1803085 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1802852 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1802855 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1803069 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1803083 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1802846 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1802851 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1802849 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1802845 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1803079 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1802854 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1802850 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1803072 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1802847 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1802842 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1802356 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1179821 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1802848 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1803067 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1803073 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1803068 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1802853 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1802844 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1802843 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1802357 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1803084 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1803082 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL485053 | LEUCETTAMINE B | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1803071 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1802841 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1802355 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1803070 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1802856 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1802857 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1803081 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803076 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803075 | — | IC50 | > | 10000.0 | nM | - |