Assay Detail
Binding
CHEMBL1805102
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Inhibition of mouse recombinant GST-tagged CLK3 using GRSRSRSRSRSR as substrate
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK3 (CHEMBL1075282) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.66 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802356 | — | — | 1 | 6.44 |
| CHEMBL1802849 | — | — | 1 | 6.29 |
| CHEMBL1803085 | — | — | 1 | 6.28 |
| CHEMBL1803083 | — | — | 1 | 6.21 |
| CHEMBL1802848 | — | — | 1 | 6.06 |
| CHEMBL1802846 | — | — | 1 | 6.05 |
| CHEMBL1803067 | — | — | 1 | 6.03 |
| CHEMBL1802847 | — | — | 1 | 6.02 |
| CHEMBL1802845 | — | — | 1 | 5.96 |
| CHEMBL1802843 | — | — | 1 | 5.92 |
| CHEMBL1802844 | — | — | 1 | 5.70 |
| CHEMBL1802842 | — | — | 1 | 5.68 |
| CHEMBL1803079 | — | — | 1 | 5.66 |
| CHEMBL1802852 | — | — | 1 | 5.51 |
| CHEMBL1802841 | — | — | 1 | 5.50 |
| CHEMBL1803073 | — | — | 1 | 5.44 |
| CHEMBL1803082 | — | — | 1 | 5.43 |
| CHEMBL1803070 | — | — | 1 | 5.41 |
| CHEMBL1802853 | — | — | 1 | 5.41 |
| CHEMBL1803069 | — | — | 1 | 5.34 |
| CHEMBL1179821 | — | — | 1 | 5.30 |
| CHEMBL485053 | LEUCETTAMINE B | — | 1 | 5.19 |
| CHEMBL1802854 | — | — | 1 | 5.16 |
| CHEMBL1802855 | — | — | 1 | 5.10 |
| CHEMBL1803078 | — | — | 1 | 5.06 |
| CHEMBL1802355 | — | — | 1 | 5.00 |
| CHEMBL1803076 | — | — | 1 | - |
| CHEMBL1803072 | — | — | 1 | - |
| CHEMBL1803071 | — | — | 1 | - |
| CHEMBL1803068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802356 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1802849 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1803085 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1803083 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1802848 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL1802846 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1803067 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1802847 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1802845 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1802843 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1802844 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1802842 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1803079 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1802852 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1802841 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1803073 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1803082 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1803070 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1802853 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1803069 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1179821 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL485053 | LEUCETTAMINE B | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1802854 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1802855 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1803078 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1802355 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1802358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802357 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802850 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802851 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803081 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802856 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802857 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803068 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803071 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803072 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803076 | — | IC50 | > | 10000.0 | nM | - |