Assay Detail
Binding
CHEMBL1805149
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Inhibition of HIV1 reverse transcriptase L100I mutant
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.09 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223769 | — | — | 1 | 6.70 |
| CHEMBL225004 | — | — | 1 | 6.60 |
| CHEMBL1688496 | — | — | 1 | 6.00 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.05 |
| CHEMBL1688513 | — | — | 1 | - |
| CHEMBL1688575 | — | — | 1 | - |
| CHEMBL1688505 | — | — | 1 | - |
| CHEMBL1688504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223769 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL225004 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1688496 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1688513 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL1688575 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL1688505 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL1688504 | — | IC50 | > | 400000.0 | nM | - |