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Assay Detail

CHEMBL1805293

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells after 72 hrs by MTS assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.
Takeuchi T, Oishi S, Watanabe T, Ohno H, Sawada J, Matsuno K, Asai A, Asada N, Kitaura K, Fujii N.
J Med Chem (2011) 54 : 4839 -4846
PubMed 21599002 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.00 7.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1802990 1 7.04
CHEMBL1803020 1 6.96
CHEMBL1803019 1 6.96
CHEMBL1222153 1 6.55
CHEMBL1803017 1 6.42
CHEMBL1802989 1 6.21
CHEMBL1802986 1 6.09
CHEMBL1803021 1 5.96
CHEMBL243668 1 5.96
CHEMBL1802987 1 5.85
CHEMBL243883 1 5.82
CHEMBL1803022 1 5.57
CHEMBL1803018 1 5.40
CHEMBL1803016 1 5.30
CHEMBL1173704 1 5.11
CHEMBL1802988 1 4.80
CHEMBL1802991 1 -
CHEMBL1802985 1 -
CHEMBL1802984 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1802990 IC50 = 91.0 nM 7.04
CHEMBL1803020 IC50 = 110.0 nM 6.96
CHEMBL1803019 IC50 = 110.0 nM 6.96
CHEMBL1222153 IC50 = 280.0 nM 6.55
CHEMBL1803017 IC50 = 380.0 nM 6.42
CHEMBL1802989 IC50 = 610.0 nM 6.21
CHEMBL1802986 IC50 = 810.0 nM 6.09
CHEMBL1803021 IC50 = 1100.0 nM 5.96
CHEMBL243668 IC50 = 1100.0 nM 5.96
CHEMBL1802987 IC50 = 1400.0 nM 5.85
CHEMBL243883 IC50 = 1500.0 nM 5.82
CHEMBL1803022 IC50 = 2700.0 nM 5.57
CHEMBL1803018 IC50 = 4000.0 nM 5.40
CHEMBL1803016 IC50 = 5000.0 nM 5.30
CHEMBL1173704 IC50 = 7800.0 nM 5.11
CHEMBL1802988 IC50 = 16000.0 nM 4.80
CHEMBL1802991 IC50 > 63000.0 nM -
CHEMBL1802985 IC50 > 200000.0 nM -
CHEMBL1802984 IC50 - -