Assay Detail
Binding
CHEMBL1805306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of human PXR expressed in HepG2 cells after 18 hrs by luciferase reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.47 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1617 | RIFAXIMIN | 4.0 | 1 | 5.66 |
| CHEMBL1649712 | SOLOMONSTEROL A | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1617 | RIFAXIMIN | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1649712 | SOLOMONSTEROL A | EC50 | = | 5200.0 | nM | 5.28 |