Assay Detail
Functional
CHEMBL1805383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Shh Light II |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.49 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480889 | — | — | 1 | 7.00 |
| CHEMBL254129 | CYCLOPAMINE | — | 1 | 6.52 |
| CHEMBL1803109 | DESMETHYLVERAMILINE | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480889 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL254129 | CYCLOPAMINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1803109 | DESMETHYLVERAMILINE | IC50 | = | 1100.0 | nM | 5.96 |