Assay Detail
Binding
CHEMBL1805490
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Inhibition of NF-kappaB expressed in human HEK293 cells by luciferase reporter gene based luminometric analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.23 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802270 | — | — | 1 | 5.86 |
| CHEMBL1802277 | — | — | 1 | 5.71 |
| CHEMBL1802272 | — | — | 1 | 5.68 |
| CHEMBL1802268 | — | — | 1 | 5.61 |
| CHEMBL1802273 | BENZO[B]PHENAZINE | — | 1 | 5.61 |
| CHEMBL1802258 | — | — | 1 | 5.32 |
| CHEMBL1802202 | — | — | 1 | 5.29 |
| CHEMBL60718 | TPCK | — | 1 | 5.29 |
| CHEMBL1802204 | — | — | 1 | 5.27 |
| CHEMBL1802266 | — | — | 1 | 5.18 |
| CHEMBL1802259 | — | — | 1 | 5.04 |
| CHEMBL1802264 | — | — | 1 | 4.88 |
| CHEMBL1802267 | — | — | 1 | 4.79 |
| CHEMBL1802269 | — | — | 1 | 4.77 |
| CHEMBL1802196 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802270 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL1802277 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL1802272 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1802268 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL1802273 | BENZO[B]PHENAZINE | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL1802258 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL1802202 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL60718 | TPCK | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL1802204 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL1802266 | — | IC50 | = | 6640.0 | nM | 5.18 |
| CHEMBL1802259 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL1802264 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL1802267 | — | IC50 | = | 16170.0 | nM | 4.79 |
| CHEMBL1802269 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1802196 | — | IC50 | = | 73000.0 | nM | 4.14 |