Assay Detail
Binding
CHEMBL1805588
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of histidine-tagged human recombinant IDO expressed in bacterial strain BL21 AI using L-Trptophan as substrate measured at 490 nm wavelength after 6 min by colorimetric assay
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 5.16 | 5.16 |
| IC50 | 1 | 4.04 | 4.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | — | 1 | 5.16 |
| CHEMBL1802300 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL1802300 | — | IC50 | = | 92000.0 | nM | 4.04 |