Assay Detail
Binding
CHEMBL1805699
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Inhibition of PDE4D
21
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.97 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253083 | — | — | 2 | 9.49 |
| CHEMBL1801156 | — | — | 1 | 9.46 |
| CHEMBL1801161 | — | — | 1 | 9.34 |
| CHEMBL1801155 | — | — | 1 | 9.29 |
| CHEMBL1801157 | — | — | 1 | 9.28 |
| CHEMBL1801160 | — | — | 1 | 9.28 |
| CHEMBL1801068 | — | — | 1 | 9.27 |
| CHEMBL1801151 | — | — | 1 | 9.26 |
| CHEMBL1801154 | — | — | 1 | 9.24 |
| CHEMBL1801067 | — | — | 2 | 9.24 |
| CHEMBL1801159 | — | — | 1 | 9.18 |
| CHEMBL1801071 | — | — | 1 | 9.07 |
| CHEMBL1801070 | — | — | 1 | 9.06 |
| CHEMBL372575 | — | — | 1 | 9.00 |
| CHEMBL1801158 | — | — | 1 | 9.00 |
| CHEMBL1801069 | — | — | 1 | 8.34 |
| CHEMBL485629 | MK-0873 | 2.0 | 1 | 8.29 |
| CHEMBL1801153 | — | — | 1 | 7.77 |
| CHEMBL1801152 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253083 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL1801156 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL1801161 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL1801155 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL1801160 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL1801157 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL253083 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL1801068 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL1801151 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL1801067 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL1801154 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL1801159 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL1801071 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL1801070 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL372575 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1801158 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1801067 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1801069 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL485629 | MK-0873 | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL1801153 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1801152 | — | IC50 | = | 32.0 | nM | 7.50 |